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Our liquid handling expertise enables reliable automation of high complexity molecular diagnostic techniques – such as cytogenetics (karyotyping and FISH) and molecular cytogenetics (aCGH/array comparative genomic hybridization) – for a range of applications, from metabolic diseases and cancers to reproductive genetics and transplantation medicine.
The portfolio covers the key stages of cytogenetics and molecular cytogenetics workflows, from standardized workstations with validated applications and dedicated user interfaces to highly customized platforms developed in collaboration with Tecan Labwerx.
Read how Prof. Dr. med. Claudia Haferlach from the Munich Leukemia Laboratory (MLL) uses Tecan to automate their cytogenics workflows.
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Tab 01 / Cytogenetics
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Our automated solutions cover key stages of clinical workflows for karyotyping and FISH, including hypotonic and fixation treatments of cell cultures, and the pipetting of cell suspension drops onto slides.
Show moreOur customized metaphase harvesters offer consistently high quality metaphase spreads from blood cultures. Automation eliminates labor-intensive and repetitive tasks, such as centrifugation of cell suspensions, aspiration and safe disposal of supernatants, hypotonic pre-treatment, and fixation of cells. These steps are carried out in a one-step protocol under controlled environmental conditions, without the need for user interaction, enhancing the quality and reproducibility of the process.
Metaphase spreading onto glass slides is influenced by temperature and humidity. Our dedicated solution provides optimal conditions for spreading cell suspensions onto glass slides, and improves throughput by aspirating water before the suspended cells. This ensures consistent sample spreading and helps to prevent cross-contamination.
A standard Freedom EVO is configured to process and spread 48 samples onto barcoded slides.
The barcode scanner on the pipetting arm checks the sample rack and slide IDs for the first 24 slides then, once processing of these is complete, the next sample rack and 24 slides are scanned.
A Matrix 2D barcode scanner can be mounted at the lower tip ejection position of one of the Freedom EVO workstation’s pipetting arms, allowing the identification of 2D barcodes on tube lids positioned in the cooled carrier.
A second Matrix 2D barcode scanner – mounted at the lower tip ejection position of a second pipetting arm – can be used to read the 2D barcodes on microscope slides positioned in the slide carriers. Each liquid channel of this arm is equipped with a vacuum valve and adapter to allow transport of 10 mm diameter cover slips, as well as a vacuum sensor to detect if a cover slip is not attached correctly. These sensors can be polled via Freedom EVOware software commands.
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Tab 02 / Molecular Cytogenetics
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The automation of aCGH workflows requires quantification and normalization of DNA, quality control measurements, DNA labeling by random priming, mixing, and loading of DNA samples onto the microarray.
DNA quantification is performed using the Promega QuantiFluor® ONE dsDNA System that quantifies dsDNA without binding to ssDNA, RNA or protein contaminants.
Show moreAutomation offers rapid DNA and RNA quantification with excellent sensitivity for fluorescence- and UV-based analyses, as well as normalization to your target concentration.
Read more
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Tab 03 / Software
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Tab 04 / Literature
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Fully automated liquid handling and robotics for life sciences and diagnostics
Array comparative genomic hybridization enables genome-wide screening of copy number variations with high resolution. aCGH more and more replaces karyotyping as a routine diagnostic tool for the detection of cryptic chromosomal anomalies in patients with developmental delays, ...
The DNA quantitation is critical for applications such as NGS, qPCR and molecular cytogenetics applications. Quantitation and normalization can easily be automated on a Freedom EVO work station with an integrated Infinite 200 reader.
With an ever-increasing workload, Germany’s Munich Leukemia Laboratory has automated its cytogenetics protocols on five Freedom EVO® workstations, enabling leaner, standardized, more effi cient processing and minimizing the potential for human error
The Necker Hospital for Sick Children has automated its comparative genomic hybridization workflow on a Freedom EVO® workstation, increasing throughput more than 10-fold while significantly improving reproducibility and process security.
Specialist laboratories engaged in molecular genetics and cytogenetics are turning to automation to cope with ever-increasing sample numbers, implementing tailored solutions designed to handle a range of materials and meet specific testing needs.
Human genetics and drug discovery are now inextricably linked, with large pharmaceutical companies, small biotech and even academic laboratories turning to sequencing data to identify potential targets for new therapies. But is this information being used to the best effect? And does genetic testing have a role to play in helping today's patients as well as tomorrow’s? Dr Pierre-Alain Menoud, Scientific Manager for Molecular Diagnostics at Unilabs in Lausanne, Switzerland, discusses the potential benefits of genetic testing for both the understanding and treatment of disease.
The Necker Hospital for Sick Children has automated its comparative genomic hybridization workflow on a Freedom EVO® workstation, increasing throughput more than 10-fold while significantly improving reproducibility and process security.
Tecan and the Integrated BioBank of Luxembourg (IBBL) have successfully co-developed an automated platform for buffy coat extraction based on a Freedom EVO® 200 workstation, relieving scientific staff from this time-consuming task and significantly increasing the yield of DNA.
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For research use only.