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    Smart extraction consumables

    Smart sample preparation

    Tecan's offers an extensive range of smart consumables that can be easily integrated into automated liquid handling workstations and sample prep workflows for mass spec applications.

    Sample enrichment and clean-up techniques are offered for a wide variety of proprietary extraction technologies, enabling more efficient MS sample prep workflows.

     

    Related products:  Resolvex® M10  |   Resolvex® A200
    Overview
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    MSIA




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    Tab 01 / Overview
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    From microparticulate sorbents to affinity capture to TICE™ (Tecan Immobilized Coating Extraction), as well as various enrichment and clean-up techniques, our proprietary extraction technologies simplify a broad array of sample preparation workflows for MS applications.

    Cleaner samples reduce ion suppression and the number of interfering peaks in LC-MS analysis. Our microparticulate sorbents contain extra small flow paths, ensuring the analyte molecules maintain contact with the sorbent as they pass through the sorbent bed. This enables the various components of the sample matrix – including salts, proteins, fatty acids and phospholipids – to be easily removed.

    Related products
    Positive pressure workstations

    The Resolvex smart extraction consumables have been optimized to work with our suite of Resolvex positive pressure SPE workstations.




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    Tab 02 / NBE and Cerex
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    NBE and Cerex®

    Narrow Bore Extraction columns

    Our proprietary narrow bore extraction (NBE) technology enables a fundamental redesign of the SPE workflow, with clear improvements.

    • Novel air gap prevents sample flow until positive pressure is applied, allowing extended incubation steps in the column
    • 5x smaller elution volumes – micro-elution – enables direct injection into the MS instrument, eliminating evaporation steps
    • Narrower particle size distribution improves extraction efficiency
    • Reduced sample size means faster sample prep and more efficient workflows
    • Cleaner samples adding analytical column lifetime
    Show more

    Cerex® columns

    Cerex columns feature a unique polymeric microparticulate material with a high ion exchange capacity. Both strong cation and strong anion exchange columns are available.

    • Strong cation exchange (PSCX)
      - monodispersed particles
      - for extraction of drugs from urine
    • Strong anion exchange (PSAX)
      - high ion exchange capacity
      - for drugs of abuse and pharmaceutical compound clean-up from biological fluids
    • Water wettable polymer (WWP2)
      - hydrophilic-lipophilic balance
      - for acidic, basic and neutral analytes
      - ensures reliable removal of phospholipids
    • OFXQ and OFQC
      - for extraction from saliva
    • Trace-N and Trace-N20
      - end-capped, hydrophobic, C18-bonded silica
      - most common stationary phase
      - concentrates pesticides, herbicides and other organic contaminants
      - for extraction of hormones and drugs from biofluids
    Show more

    Would you like to learn more about
    Cerex® and Narrow Bore Extraction™ (NBE™) smart consumables?

    More Information!

    Related products
    Positive pressure workstations

    The Resolvex smart extraction consumables have been optimized to work with our suite of Resolvex positive pressure SPE workstations.




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    Tab 03 / AC Plate
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    AC Extraction Plate™

    The AC Extraction Plate simplifies LC-MS sample prep for apolar small molecules, such as vitamin D, certain therapeutic drugs and testosterone. It speeds up your sample prep routine, and is a perfect match to our Freedom EVO® and Fluent® liquid handling platforms.

    Learn more

    Workflow and benefits

    The AC Extraction Plate with TICE™ (Tecan Immobilized Coating Extraction) technology revolutionizes your sample preparation routine. A simple pipette and shake sequence is all that is required, with no filtration, centrifugation or solvent evaporation steps. The AC Extraction Plate is easily integrated into automated processes, making it a perfect match for Freedom EVO and Fluent liquid handling platforms.

    COST EFFECTIVE

    A simple pipette and shake workflow. No labor-intensive centrifugation, filtration or solvent evaporation steps.

    CONVENIENT AND FAST

    Just unpack and start, no conditioning or other preparation needed. The entire sample prep protocol is completed in 30-35 min.

    HIGHLY REPRODUCIBLE

    Pipette and shake routines are easily standardized and automated on a liquid handling platform, eliminating random errors and increasing consistency of results.

    AC Extraction Plate steps

    Videos

    AC Extraction Plate

    Presentation of the AC Extraction Plate and visualization of the step-by-step sample extraction process.

    Using the AC Extraction Plate with the Freedom EVO and TouchTools™

    The AC Extraction Plate offers easy automation on a Freedom EVO liquid handling platform. Clear instructions and information are provided by the TouchTools interface during the sample preparation process.

    AC Extraction Plate – Interview at Analytica 2014

    Explanation of the benefits of the AC Extraction Plate, and how this can help the customers to simplify their sample prep routines for apolar small molecules.

    Clozapine therapeutic drug monitoring at King’s College Hospital, London

    A senior clinical scientist explains how the AC Extraction Plate has helped them to save time and costs for the analysis of clozapine.

    Related products
    Freedom EVO series

    One reliable platform, unlimited options, individual solutions.

    Fluent series

    Simplify your lab with industry-leading, application-focused automation.

    Brochures
    Applications

    For research use only.




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    Tab 04 / Literature
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    Application notes – AC Extraction Plate™

    A simple procedure for the extraction of antidepressants from whole blood for LC-MSMS analysis

    This application note shows how antidepressants were quantified from whole blood, using samples spiked with standards and authentic samples from impaired drivers.

    Estradiol – Simple Sample Preparation Procedure for Quantitative Analysis by LC-MS/MS

    Application note showing how the AC Extraction Plate can be used for the quantification of estradiol from serum samples.

    Sample preparation with the AC Extraction Plate: extraction of urinary THC metabolites for LC-MSMS quantification

    In this application note describes a method for sample prep and quantitative analysis of THC from urine.

    Quantitative Determination of Serum 25-OH-vitamin D3/D2 using the Tecan AC Extraction Plate ™ and the Bruker amaZon speed Ion Trap (LCMS-95)

    In this application note, a method for sample prep and quantitation of 25-OH-vitamin D is presented.

    Automated sample preparation for the determination of testosterone in serum by LC-MSMS

    An automated method for the determination of testosterone in serum by LC-MS using a Freedom EVO liquid handling platform is presented.

    Automated Sample Preparation of 25-OH-Vitamin D3/D2 from Serum with the Tecan Freedom® EVO

    An application note describing a method for automated sample preparation for vitamin D analysis on the Freedom EVO liquid handling platform.

    A unique sample preparation method for the extraction of ibuprofen from urine for LC-MSMS quantification

    The application note presents a method for sample prep and quantitation of the painkiller ibuprofen in pig urine.

    Simple sample preparation for the determination of vitamin D in serum by LC-MS/MS

    This application covers a method for sample prep and LC-MS quantification of Vitamin D with the AC Extraction Plate. Day-to-day variability is also investigated and documented.

    Technical notes – AC Extraction Plate

    Simplified method development with the AC Extraction Plate

    A technical description of how the AC Extraction Plate simplifies sample preparation, and which types of analytes this product is particularly suitable for.

    Effectiveness of the AC Extraction Plate for protein removal

    This technical note presents evidence that the extracts from the AC Extraction Plate are free of proteins.

    Extractables do not affect downstream vitamin D analysis by LC-MS/MS

    This technical note shows that extractables, which potentially come from labware, have no influence on vitamin D analysis by LC-MS with respect to ion suppression

    Using the Tecan AC Extraction Plate for sample preparation - A screening study

    In this technical note, a preliminary screening of several dozen analytes is performed, and the outcome is discussed on the basis of structure-activity relationships

    Ensuring reproducible extraction performance through routine quality control

    This technical note describes quality control procedures in detail.

    White paper – AC Extraction Plate

    Technical Background to the Tecan AC Extraction Plate

    This white paper explains in detail the technology of the AC Extraction Plate, providing information on the extraction steps and showing which analytes it can be used for. It also contains a Q&A section.

    Posters – AC Extraction Plate

    Simple extraction of antidepressants from whole blood for LC-MSMS analysis using coated well plates

    Poster displaying the results of using the AC Extraction Plate for extraction and LC-MSMS analysis of anti-depressants

    Sample preparation of multiple steroids for quantitative determination by LC-MS/MS – comparison of two extraction procedures

    Poster comparing the AC Extraction Plate with another commercially available consumable for the extraction of multiple steroids in one run.

    1,25-di-hydroxy Vitamin D analysis by LC-MS: Optimization for sample prep automation and medium throughput lab

    Poster presenting the results for automated sample prep and LC-MS quantification of vitamin D.

    Rapid, fully-automated plasma Clozapine and NOR-Clozapine analysis using Tecan AC Extraction Plate technology and isotopic internal calibration MS/MS

    Poster describing how the AC Extraction Plate and the Freedom EVO liquid handling platform can be used for therapeutic drug monitoring of clozapine.

    Estradiol - Investigation of two Sample Preparation Procedures for Quantitative Analysis by LC-MS/MS

    This poster compares two different sample prep procedures for estradiol.

    Easy to automate extraction of THC-metabolites for LC-MS/MS analysis (Ameritox)

    This poster presents an automated method for the extraction and quantification of THC metabolites for LC-MS

    Automated Sample Preparation of Biological Fluids for LC-MS/MS Analysis

    This poster describes how the AC Extraction Plate can be automated on a Freedom EVO liquid handling platform.
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